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MDCAT
Biology
2015

Biology · Cell Cycle

Work through this past-paper style MCQ, then read the full explanation. Practice more biology questions on mMCQ with adaptive practice and topic analytics.

Question

The disease in which an individual has extra sex chromosome (44 + XXY) is known as:

Options
  • A

    Down’s syndrome

  • B

    Turner's syndrome

  • C

    Klinefelter’s syndrome

  • D

    Jacob’s syndrome

Explanation

Klinefelter's syndrome is a genetic disorder that affects males, characterized by the presence of an extra X chromosome. The most common karyotype in Klinefelter's syndrome is 47 + XXY, indicating an additional X chromosome. Individuals with Klinefelter's syndrome may have physical, hormonal, and developmental differences. 

Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of an extra copy of chromosome 21. It is characterized by distinct physical features, intellectual disability, and developmental delays. The karyotype of individuals with Down's syndrome is 47 + XX or 47 + XY. 

This option is not the correct answer. Turner's syndrome is a genetic disorder that affects females, characterized by the absence of one X chromosome or significant abnormalities in the X chromosome. The karyotype of individuals with Turner's syndrome is 45 + X. 

This option is the correct answer. Klinefelter's syndrome is a genetic disorder that affects males, characterized by the presence of an extra X chromosome. The most common karyotype in Klinefelter's syndrome is 47 + XXY, indicating an additional X chromosome. Individuals with Klinefelter's syndrome may have physical, hormonal, and developmental differences. 

Jacob's syndrome, also known as XYY syndrome, is a genetic condition in males where there is an extra Y chromosome, resulting in a karyotype of 47 + XYY. This syndrome is associated with tall stature and behavioral differences, but it is generally not associated with severe physical or cognitive impairments. 

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Tagged under Biology · Cell Cycle · 2015