Induced Fit Hypothesis for Neuraminidase

Steps:

• Recall induced fit: substrate binding causes enzyme conformational change for precise fit.
• Identify key feature: enzyme active site adjusts shape, unlike rigid lock-and-key model.
• Evaluate statements (assuming standard): 1 likely describes rigid site (wrong); 2 may mix models; 3 states enzyme shape change (correct).
• Select option matching only correct statement: D (3 only).

Why D is correct:

• Induced fit defines enzyme undergoing conformational change upon substrate binding, as per Koshland's model.

Why the others are wrong:

• A includes 1 (rigid site contradicts induced fit).
• B includes 2 (often incorrect or partial, mixing with lock-and-key).
• C focuses on 2 only (incomplete if 2 is wrong).

Not enough information on exact statements 1-3.

Final answer: D