A Levels Biology (9700)•9700/12/O/N/22

Explanation
Blood Flow Dynamics in VSD
Steps:
- Left ventricle generates higher pressure than right ventricle due to systemic resistance.
- Hole in septum allows blood to shunt from left (high pressure) to right (low pressure) ventricle.
- This left-to-right shunt recirculates oxygenated blood to lungs, increasing pulmonary volume.
- Systemic circulation receives normally oxygenated blood, maintaining tissue delivery.
Why D is correct:
- Left-to-right shunting in VSD elevates pulmonary blood flow (statement 2) while preserving normal systemic oxygenation (statement 3), per pressure gradient principles.
Why the others are wrong:
- A, B, C all include statement 1, which reverses the shunt direction (right-to-left occurs only if pulmonary hypertension develops later).
Final answer: D
Topic: The heart
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