A Levels Biology (9700)•9700/13/M/J/24

Explanation
Primary Immune Response Sequence
Steps:
- Pathogens enter body; macrophages phagocytose them (event 2) to process antigens.
- Processed antigens presented via surface molecules, including initial antibody display on B cells (event 4).
- T-helper cells activate (event 3), aiding cytotoxic T-killer production and B cell stimulation.
- Activated B cells differentiate into plasma and memory cells (event 1), leading to antibody production and release (event 5).
Why B is correct:
- Matches innate-to-adaptive progression: phagocytosis initiates antigen presentation (2-4), T-cell help (3) drives B-cell activation (1) and humoral response (5), per immunology's stepwise activation model.
Why the others are wrong:
- A: Starts with antibody release (5), skipping innate phagocytosis.
- C: Places T-helper activation (3) before B-cell differentiation (1), inverting helper-B cell dependency.
- D: Begins with unclear surface antibody release (4), preceding phagocytosis needed for antigen processing.
Final answer: B
Topic: The immune system
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