A Levels Biology (9700)•9700/11/M/J/21

Explanation
Sister Chromatids Joined at Centromere in Early Mitosis
Steps:
- Replicated chromosomes enter mitosis as two sister chromatids joined at the centromere.
- In prophase, chromosomes condense, making the paired chromatids visible and attached.
- In metaphase, chromosomes align at the equator with centromeres intact, holding chromatids together.
- In anaphase, centromeres split, separating chromatids to opposite poles.
Why C is correct:
- Prophase and metaphase occur before centromere division, so sister chromatids remain attached per mitosis stage definitions.
Why the others are wrong:
- A: Anaphase separates chromatids; telophase features decondensing individual chromosomes.
- B: Anaphase involves chromatid separation, unlike prophase.
- D: Telophase follows separation, with chromatids as distinct chromosomes.
Final answer: C
Topic: Chromosome behaviour in mitosis
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