A Levels Biology (9700)•9700/13/M/J/19

Explanation
Silent Mutation Steps:
- Divide sequences into 5 codons of 3 bases each, assuming coding strand (T to U for mRNA equivalent).
- Translate codons to amino acids using standard genetic code: original CCA (Pro), TTC (Phe), GGC (Gly), TTA (Leu), GCA (Ala).
- Compare each option's amino acid sequence to original Pro-Phe-Gly-Leu-Ala.
- Identify option with identical sequence, indicating no change in polypeptide.
Why B is correct:
- Third codon GGC (Gly) mutates to GGA (Gly), a silent mutation due to degeneracy in the genetic code's third ("wobble") position.
Why the others are wrong:
- A: Second codon TTC (Phe) to ATC (Ile), missense mutation changes amino acid.
- C: First codon CCA (Pro) to CTT (Leu), plus other changes like third GGC (Gly) to GCG (Ala), alters multiple amino acids.
- D: Second codon TTC (Phe) to TCG (Ser), plus others like fifth GCA (Ala) to GAA (Glu), alters multiple amino acids.
Final answer: B
Topic: Protein synthesis
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