Monoclonal Antibodies Targeting Cancer Mechanisms

Steps:

• Cancer monoclonal antibodies work by marking tumor cells for immune destruction, enhancing T-cell activity against tumors, or inhibiting cancer cell growth signals.
• Evaluate statement 1: Binding to cell surface proteins flags cancer cells, triggering immune attack—effective for cancer.
• Evaluate statement 2: Blocking inhibitory molecules on cells activates T-cells to target tumors—key in immunotherapy.
• Evaluate statement 3: Blocking receptors that promote cell division halts cancer proliferation—directly anti-cancer.
• Evaluate statement 4: Blocking immune response receptors suppresses anti-tumor immunity—harmful for cancer treatment.

Why B is correct:

• B selects 1, 2, and 3, matching cancer mAb strategies like rituximab (1), PD-1 inhibitors (2), and trastuzumab (3) that attack tumors without suppressing immunity.

Why the others are wrong:

• A includes 4, which blocks immune responses and weakens anti-cancer effects.
• C includes 4 (immunosuppressive) and excludes 2 (essential T-cell activation).
• D omits 1 and 3 (tumor targeting and growth inhibition) while including harmful 4.

Final answer: B