O Levels Biology (5090)•5090/11/O/N/24

Explanation
Recombinant insulin avoids animal-derived risks
Steps:
- Identify the type: This refers to human insulin produced via recombinant DNA technology in bacteria or yeast, mimicking the human protein exactly.
- Compare to alternatives: Traditional insulin came from animal pancreases (pigs, cows), which could cause immune reactions.
- Evaluate advantages: Recombinant method produces pure human insulin, reducing side effects like allergies or impurities.
- Match to choices: Select the option highlighting elimination of animal insulin issues.
Why D is correct:
- Recombinant insulin is identical to human insulin, eliminating side effects from animal proteins due to antigenic differences, as per immunology principles of foreign protein rejection.
Why the others are wrong:
- A: Genetic therapy doesn't alter patient's germline DNA, so offspring aren't protected.
- B: This production method supplies external insulin; it doesn't repair or stimulate the patient's pancreas.
- C: The insulin gene is inserted into host cells (e.g., bacteria) for production, not into the patient's DNA.
Final answer: D
Topic: Genetic modification
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