O Levels Biology (5090)•5090/12/O/N/19

Explanation
X-linked recessive inheritance probability for male offspring
Steps:
- Night-blindness is X-linked recessive; males express the trait if they inherit the allele from carrier mother.
- Probability unborn child is male: 1/2.
- If male, probability of inheriting recessive allele from heterozygous mother: 1/2 (mother passes X with allele half the time).
- If mother’s carrier status is uncertain (e.g., 1/2 chance based on pedigree), multiply by 1/2: overall 1/2 × 1/2 × 1/2 = 1/8.
Why C is correct:
- 1/8 matches the product of independent probabilities: sex (1/2), maternal carrier status (1/2), and allele transmission (1/2) per Mendel's law of segregation.
Why the others are wrong:
- A: Ignores genotype probability, assumes only 1/2 male chance.
- B: Assumes certain carrier mother, omitting status uncertainty (1/2 × 1/2 = 1/4).
- D: Overestimates by including female carriers or unaffected outcomes.
Final answer: C
Topic: Inheritance
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